Spatial CUT&Tag

Map Histone Modifications and Chromatin-Bound Proteins

Spatial CUT&Tag for histone marks & chromatin-bound proteins

Antibody-guided Tn5 tagmentation maps chromatin modifications and protein–DNA occupancy directly on tissue sections, preserving morphology and neighborhood context.

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Targeted epigenomic readout
Profile activating, repressive, and architectural signals with spatial precision.
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Gentle, streamlined workflow
On-slide binding and tagmentation reduce handling—well suited to delicate tissues and co-registration with H&E.
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Quantitative spatial signals
Call peaks, compute enrichment, and relate programs to cell neighborhoods.
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Complementary to Spatial ATAC
Layer CUT&Tag occupancy with accessibility to strengthen regulatory interpretation.

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Diagram showing the structure of an antibody with labeled regions including the antigen-binding sites, primary and secondary antibody regions, and nucleosomes indicated with coil-like structures.

A scientific chart with multiple panels showing data visualizations, including a spatial UMAP plot, gene activity score map, gene expression peaks, and a sequence track labeled "Encode Pseudobulk".

A broad range of targets have been validated for spatial CUT&Tag

ASHG 2025 Poster — Spatial CUT&Tag

Exhibit & Poster Hall • Board 8057T

Spatial epigenomic profiling reveals the chromatin mechanisms driving tumor resistance and cellular heterogeneity. Using AtlasXomics’ spatial CUT&Tag and DBiT-seq platforms, we mapped histone modifications and chromatin accessibility across gastric and prostate tumors, uncovering group-specific enhancer activity, altered chromatin looping, and transcription factor networks linked to tumor-stroma interactions. These results demonstrate how spatial epigenomics exposes the regulatory architecture of cancer within its native tissue context.

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