Map histone marks with spatial precision.
Antibody-guided Tn5 tagmentation maps chromatin modifications and protein–DNA occupancy directly on tissue sections — preserving morphology and neighborhood context.
Platform Specs
Resolution
10 × 10 µm
Spots per chip
48,400+
Sample type
Fresh-Frozen
Targets
Histone marks
& TF binding
& TF binding
01 — Technology
Spatial CUT&Tag for histone marks & chromatin-bound proteins
Profile activating, repressive, and architectural chromatin signals with the same spatial precision as ATAC-seq — using antibody-directed tagmentation on intact tissue sections.
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Targeted epigenomic readout Profile H3K27me3, H3K4me3, and other marks or chromatin-bound proteins with spatial precision — no cell dissociation required.
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Gentle, streamlined workflow On-slide antibody binding and Tn5 tagmentation reduce handling, making it well-suited to delicate tissues and co-registration with H&E.
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Quantitative spatial signals Call peaks, compute enrichment scores, and relate chromatin programs to cell neighborhoods and tissue architecture.
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Validated antibody compatibility Antibodies validated for bulk CUT&Tag have a high success rate with spatial CUT&Tag — your existing reagents translate directly to the spatial workflow.
Mechanism
Antibody-directed Tn5 tagmentation
Original Publication · Science 2022
Spatial-CUT&Tag: Spatially resolved chromatin modification profiling at the cellular level
AtlasVerify
Validate your antibody for spatial CUT&Tag analysis with AtlasVerify. AtlasVerify predicts assay performance from an adjacent section.
Learn more →
02 — Resources
Posters, white papers, and case studies.
Technical references and application examples for spatial CUT&Tag across diverse tissue types and chromatin targets.
Conference Poster
ASHG 2025 — Spatial CUT&Tag
Spatial epigenomic profiling reveals chromatin mechanisms driving tumor resistance and cellular heterogeneity. Histone modifications and chromatin accessibility mapped across gastric and prostate tumors — uncovering enhancer activity, chromatin looping, and transcription factor networks linked to tumor-stroma interactions.
White Paper
Spatial CUT&Tag — High-Resolution Chromatin Profiling with Spatial Context
- How spatial CUT&Tag works in situ — antibody-directed Tn5 tagmentation on tissue
- Robust profiling across diverse histone marks and chromatin targets
- Representative performance and reproducibility benchmarks
03 — Get started
Ready to map your histone marks?
Our team will help you select the right antibody targets, qualify your samples, and deliver spatial epigenomic data you can publish.