Spatial CUT&Tag

Map histone modifications and chromatin associated proteins with spatial CUT&Tag

Spatial CUT&Tag

Scientific diagram of a brain scan with labeled regions and clusters in various colors, titled 'Science' and 'Deng 2022'.

Spatial-CUT&Tag: Spatially resolved chromatin modification profiling at the cellular level

Yanxiang Deng¹ ², Marek Bartosovic³, Petra Kukanja³, Di Zhang¹, Yang Liu¹ ², Graham Su¹ ², Archibald Enninful¹ ², Zhiliang Bai¹, Gonçalo Castelo-Branco³ ⁴, Rong Fan¹ ² ⁵

Spatial CUT&Tag protocol

Diagram showing a step-by-step process of DNA barcoding with labeled steps 1 through 8, including antibody binding, transposition, barcode ligation, imaging, reverse crosslinking, sequencing, and data analysis.

Target chromatin modifications to map gene regulation

Diagram of an antibody with labeled components including nucleosomes, primary antibody, secondary antibody, histone tail modification, and pA-Tn5.

Partnership with EpiCypher to identify high-efficiency antibodies

A broad range of targets has been validated for spatial CUT&Tag

Spatial CUT&Tag: High performance, reproducibility, and sensitivity